FOXP3-engineered regulatory T cells enhance intestinal barrier function in Crohn's disease enteroids via the PDGF-AA-PDGFR axis, independent of their immunosuppressive role.

bioRxiv · May 28, 2026 · PreprintImmunology

Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis

Babajide A. Ojo, Ying Zhu, Lyong Heo, Sejal R. Fox, Yanli Qiao, Amanda Waddell, Maria E. Moreno‐Fernandez, Marielle Gibson, Tracy Tran, Ashley L. Dunn, Essam A. Elknawy, Neetu Saini, Javier A. López-Rivera, Senad Divanovic, Yuqin Dai, , Michael J. Rosen

This study uses patient-derived colon organoids to identify lipid-related metabolic dysfunction in pediatric ulcerative colitis and shows that PPAR-α inhibition can alleviate metabolic and inflammatory features.

Nature Communications · Dec 10, 2025Peer-reviewedPhysiology

The genomic landscape across 474 surgically accessible epileptogenic human brain lesions

Javier A. López-Rivera, Costin Leu, Marie Macnee, Jean Khoury, Lucas Hoffmann, Roland Coras, Katja Kobow, Nisha Bhattarai, Eduardo Pérez‐Palma, Hajo M. Hamer, Sebastian Brandner, Karl Rössler, Christian G. Bien, Thilo Kalbhenn, Tom Pieper, , Dennis Lal

This study identifies somatic and germline genetic variants in 474 epileptogenic brain lesions, revealing associations with specific epilepsy subtypes and informing clinical genetic screening.

Brain · Oct 13, 2022Peer-reviewedGenetic & Genomic Medicine