Sean J. McIlwain

The paper uses integrated mass spectrometry to show AMPK phosphorylation occurs through hierarchical proteoform cascades with specific kinetic priorities and regulatory control.

This study shows that long-term caloric restriction in rhesus monkeys leads to depot-specific changes in adipose tissue, with shared proteostasis pathways and species-conserved effects on subcutaneous fat.

The paper introduces HERON, an R package for identifying immunogenic epitopes from ultradense peptide binding arrays across multiple samples.

MASH Native provides a unified software solution for processing native top-down proteomics data, offering database searching and analysis tools in a user-friendly interface.