Timothy W. Rhoads

Caloric restriction drives age-dependent and integrated remodeling of RNA processing and lipid composition in mouse brain

This study shows that caloric restriction in mice alters RNA processing and lipid composition across adulthood, linking these changes to metabolic reprogramming and lifespan extension.

Microbial metabolism of methotrexate produces a STAT3 signaling molecule that alleviates gut inflammation

The paper identifies a gut microbial metabolite of methotrexate that alleviates gut inflammation by promoting mitochondrial STAT3 signaling.

Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism

This study shows that Ulk1(S555) phosphorylation regulates metabolic flexibility by prioritizing amino acid metabolism during nutrient stress.

Caloric restriction reprograms adipose tissues in rhesus monkeys

This study shows that long-term caloric restriction in rhesus monkeys leads to depot-specific changes in adipose tissue, with shared proteostasis pathways and species-conserved effects on subcutaneous fat.

Proteomics, lipidomics, metabolomics and 16S rDNA sequencing of dental plaque from patients with diabetes and periodontal disease

The paper integrates proteomics, lipidomics, metabolomics, and 16S rDNA sequencing to analyze dental plaque from patients with diabetes and periodontal disease, identifying microbial and host factors associated with these conditions.