Wei Wei

Natural motion statistics unify direction computations

The paper shows that retinal direction-selective ganglion cells encode motion direction by averaging motion vectors, which aligns with natural motion statistics.

Deep learning-guided design of cell type-specific AAV promoters

This study designs cell type-specific AAV promoters using deep learning, outperforming rational approaches in mouse retinal cells and showing promise for human applications.

Transmission of Mixed Convergent Signals at the Mouse Retinogeniculate Synapse

The paper investigates information transfer at the mouse retinogeniculate synapse and finds that dLGN neurons primarily relay input from specific RGC populations, supporting a labeled line model.

Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway

This study shows that tau regulates Arc stability in neuronal dendrites through a proteasome-sensitive, ubiquitin-independent pathway, affecting AMPA receptor localization and synaptic plasticity.

Arc ubiquitination regulates endoplasmic reticulum-mediated Ca2+ release and CaMKII signaling

This study shows that Arc ubiquitination regulates ER-mediated Ca2+ release and CaMKII signaling during mGluR-LTD.

Visual stimulation induces distinct forms of sensitization of On-Off direction-selective ganglion cell responses in the dorsal and ventral retina

The paper shows that visual stimulation causes different sensitization patterns in dorsal and ventral On-Off direction-selective ganglion cells, with dorsal cells showing sensitization of both On and Off responses while ventral cells only show Off response sensitization.

Spatially displaced excitation contributes to the encoding of interrupted motion by the retinal direction-selective circuit

The paper investigates how spatially displaced excitation influences the direction selectivity of On-Off DSGCs during interrupted motion, showing its role in encoding visual features.

High-fat diet induced loss of GABAergic inhibition decouples intrinsic and synaptic excitability in AgRP neurons

This study shows that high-fat diet causes AgRP neurons to lose GABAergic inhibition, leading to persistent hyperexcitability despite increased inhibitory input.