Meinan Lyu

The E. coli DnaX clamp loader sharply bends DNA to load β-clamp at nicks and small gaps

This paper shows the E. coli DnaX clamp loader uses DNA bending instead of unwinding to load β-clamp at nicks and small gaps, revealing a distinct bacterial mechanism for DNA repair.

Elucidating the dynamics of Integrin αIIb3 from native platelet membranes by cryo-EM with build and retrieve method

This paper uses cryo-EM with the Build-and-Retrieve method to solve integrin αIIbβ3 structures from resting human platelet membranes, revealing new insights into its regulation and dimer conformation.

The Plasmodium falciparum NCR1 membrane protein is a novel antimalarial target that exports cholesterol to maintain membrane homeostasis

This paper presents three structures of PfNCR1, a Plasmodium falciparum membrane protein, and shows it exports cholesterol to maintain membrane homeostasis, with MMV009108 inhibiting this function.