Frances A. Champagne

Postnatal maternal care normalizes the hypothalamic DNA methylome following prenatal bisphenol exposure

This study shows that postnatal maternal care reduces DNA methylation changes in the hypothalamus caused by prenatal bisphenol exposure in female rats.

Postnatal maternal care moderates the effects of prenatal bisphenol exposure on offspring neurodevelopmental, behavioral, and transcriptomic outcomes

This study examines how prenatal bisphenol exposure interacts with postnatal maternal care to affect offspring neurodevelopment, behavior, and transcriptomic outcomes.

Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex

The paper identifies 46,802 enhancers and 164 psychiatric disorder variants with regulatory effects in the developing cortex and organoids using massively parallel reporter assays and deep learning.

Single-cell genomics and regulatory networks for 388 human brains

The paper processes single-nuclei multi-omics data from 388 human brains to identify regulatory elements and build cell-type networks, revealing changes in aging and neuropsychiatric disorders.

Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex

The paper generates a molecular neuroanatomical map of the human prefrontal cortex using spatial transcriptomics and single nucleus RNA-sequencing, revealing novel spatial domains and cell-cell interactions linked to psychiatric disorders.

Sex-specific effects of chronic paternal stress on offspring development are partially mediated via mothers.

This study shows that chronic paternal stress in mice leads to sex-specific effects on offspring behavior, partially mediated through changes in maternal care and investment.

Robust range of auditory periphery development, eye opening, and brain gene expression in Wistar rat pups that experience variation in maternal backgrounds

This study investigates the impact of maternal licking and grooming on auditory development and brain gene expression in Wistar rat pups, finding no effect on hearing onset timing but revealing insights into auditory periphery development and gene regulation.