Melissa Leija‐Salazar

Transcriptomic and phenotypic characterization of Alzheimer's disease risk genes in neurons and astrocytes highlights shared and cell type specific cellular mechanisms

The paper uses single-cell transcriptomics and phenotypic analysis of gene knockouts in hiPSC-derived neurons and astrocytes to identify cell-type specific and shared mechanisms of Alzheimer's disease risk genes.

Postnatal maternal care normalizes the hypothalamic DNA methylome following prenatal bisphenol exposure

This study shows that postnatal maternal care reduces DNA methylation changes in the hypothalamus caused by prenatal bisphenol exposure in female rats.

Properties of Alzheimers disease brain-derived tau aggregates define tau processing by human astrocytes.

This study shows that tau aggregates from Alzheimer's disease brains are taken up and processed by human astrocytes, with differences in handling linked to astrocyte responses and gene expression changes.

Postnatal maternal care moderates the effects of prenatal bisphenol exposure on offspring neurodevelopmental, behavioral, and transcriptomic outcomes

This study examines how prenatal bisphenol exposure interacts with postnatal maternal care to affect offspring neurodevelopment, behavior, and transcriptomic outcomes.

Detection of GBA missense mutations and other variants using the Oxford Nanopore MinION

The paper validates the use of Oxford Nanopore MinION for detecting GBA mutations, including missense variants and deletions, with accurate phasing and intronic analysis.