Evelyn L. Eastwood

The paper characterizes human MCM double hexamer (hDH) loading using biochemical reconstitution and cryo-EM, revealing differences from yeast in assembly mechanisms and identifying a novel intermediate.

The paper identifies a dual histone modification (H3K9me3 and H3K27me3) that specifies Rhino binding to a subset of piRNA source loci in Drosophila germ cells, independent of Kipferl.

This study identifies LC8/Cut-up as an essential component of the PICTS complex in Drosophila, showing its role in transposon silencing through complex dimerisation.

This study identifies Nxf3 as essential for exporting piRNA precursors from dual-strand clusters in Drosophila, ensuring proper piRNA production and transposon silencing.

The paper identifies Nxf2 and Nxt1 as factors required for piRNA-guided co-transcriptional silencing of transposons in Drosophila, showing their interaction with Panx and role in repressive chromatin formation.

The paper identifies Daedalus and Gasz as mitochondrial factors that recruit Armitage to mitochondria, facilitating piRNA precursor processing by linking nuage/Yb-body and mitochondrial biogenesis machinery.