Marzia Munafò

Systematic Epigenome Editing Captures the Context-dependent Instructive Function of Chromatin Modifications

This study uses epigenome editing to systematically analyze how chromatin modifications influence transcription, revealing context-dependent regulatory mechanisms.

Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function

This paper shows that depletion of Drosophila CNBP causes age-dependent locomotor defects linked to reduced polyamine metabolism and ODC levels, which can be rescued by polyamine supplementation or ODC overexpression.

Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila

This study identifies LC8/Cut-up as an essential component of the PICTS complex in Drosophila, showing its role in transposon silencing through complex dimerisation.

Specialization of the Drosophila nuclear export family protein, Nxf3, for piRNA precursor export

This study identifies Nxf3 as essential for exporting piRNA precursors from dual-strand clusters in Drosophila, ensuring proper piRNA production and transposon silencing.

piRNA-guided co-transcriptional silencing coopts nuclear export factors

The paper identifies Nxf2 and Nxt1 as factors required for piRNA-guided co-transcriptional silencing of transposons in Drosophila, showing their interaction with Panx and role in repressive chromatin formation.

Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery

The paper identifies Daedalus and Gasz as mitochondrial factors that recruit Armitage to mitochondria, facilitating piRNA precursor processing by linking nuage/Yb-body and mitochondrial biogenesis machinery.