Alex J. Cornish

Whole genome sequencing of endometrial cancer identifies novel subgroups, drivers, and actionable alterations

This study uses whole genome sequencing of endometrial cancers to identify novel subgroups, drivers, and actionable alterations, improving precision medicine approaches.

Identification of non-covalent inhibitors for the atypical peroxiredoxin PRDX5 as a therapeutic strategy in malignant pleural mesothelioma

The paper identifies non-covalent inhibitors of PRDX5, a protein upregulated in MPM, through a machine learning guided pipeline and biochemical validation, suggesting it as a therapeutic target.

Multi-modal benchmarking of the Ultima UG100 and Illumina NovaSeq sequencing platforms using clinically relevant FFPE tissues

This paper benchmarks the Ultima UG100 and Illumina NovaSeq platforms on FFPE tissues for various sequencing modalities, finding they produce comparable results with subtle discrepancies in non-coding transcripts.

Deciphering Cellular Ecosystems Driving Tumor Progression and Immune Escape from Spatial Transcriptomics and Single-Cell with COMPOTES

The paper introduces a machine-learning method to identify recurrent cell-cell communication patterns across tumor samples using spatial transcriptomics and single-cell data, revealing key immune and genetic programs in bladder cancer.

Histology and spatial transcriptomic integration revealed infiltration zone with specific cell composition as a prognostic hotspot in glioblastoma

The paper identifies a prognostic infiltration zone in glioblastoma using histology and spatial transcriptomic integration, revealing specific cell composition associated with long-term survival.

Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes and immune interactions

Correcting reference bias from the Illumina Isaac aligner enables analysis of cancer genomes

The paper identifies a bias in VAF estimates from the Illumina Isaac aligner and introduces FixVAF to correct it, improving cancer cell fraction analysis.