Nicolas L. Jean

The paper identifies non-covalent inhibitors of PRDX5, a protein upregulated in MPM, through a machine learning guided pipeline and biochemical validation, suggesting it as a therapeutic target.

This paper presents the cryo-EM structure of the divisome core complex FtsWIQBL from Pseudomonas aeruginosa, revealing molecular mechanisms of divisome activation and a conformational switch between inactive and active states.

The paper determines the cryo-EM structure of FtsK's motor domain translocating DNA, revealing a mechanism involving conformational changes and spiral staircase interactions.