PPARgamma, a key modulator of metabolic reprogramming, stemness and chemoresistance associated with retrodifferentiation in human hepatocellular carcinomas
Yoann Daniel, Claudine Rauch, Lucille Moutaux, Lise Desquilles, Tifenn Le Charpentier, Karim Fekir, Luis Cano, Daniel Catheline, Servane Pierre, Agnès Burel, Camille C. Savary, Catherine Ribault, Claude Bendavid, Bruno Clément, Caroline Aninat, , Anne Corlu
This study identifies PPARgamma as a key regulator of metabolic reprogramming and stemness in hepatic CSCs, linking it to chemoresistance in HCC.
Cell Death and Disease · Nov 17, 2025Peer-reviewedCancer Biology