Author

Joaquim Alves da Silva

Champalimaud FoundationORCID 0000-0002-3967-3603Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell-cell communication· 1 Assay:imaging· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Rui M. CostaiD· 3 shared Akira FushikiiD· 1 shared Andreas KlausiD· 1 shared Archana YadaviD· 1 shared Artur SilvaiD· 1 shared B. LacosteiD· 1 shared Boris S GutkiniD· 1 shared Bosiljka TasiciD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersNeuroscience

Rui M. CostaORCID

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Author profile →

4 papers

Recent·Most cited

Control of Male Mouse Copulatory Behavior by Midbrain Dopamine Neurons

Silvana C Araujo, B. Lacoste, Luis Moreira, Oihane Horno, Eran Lottem, Joaquim Alves da Silva, Boris S Gutkin, Christian K. Machens, Susana Q. Lima

This study investigates how midbrain dopamine neurons control male mouse copulatory behavior, finding that their activity is experience-independent and critical for sustaining thrusting actions during mating.

bioRxiv · Feb 22, 2026 · PreprintNeuroscience

A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson's Disease

Akira Fushiki, David Ng, Zachary Lewis, Archana Yadav, Tatiana Saraiva, Luke Alexander Hammond, Christoph Wirblich, Bosiljka Tasic, Vilas Menon, Joaquim Alves da Silva, Rui M. Costa

The paper identifies a specific subtype of dopaminergic neurons, Anxa1+, that are selectively lost in Parkinson's disease and contribute to early motor symptoms.

bioRxiv · Dec 20, 2024 · PreprintNeuroscience

Transient dopamine neuron activity precedes and encodes the vigor of contralateral movements

Marcelo Mendonça, Joaquim Alves da Silva, Ledia F. Hernández, Iván Castela, Jose Angel Obeso, Rui M. Costa

This study shows that dopamine neurons in the substantia nigra pars compacta encode contralateral movement vigor through transient activity, not general motivation.

Current Biology · Feb 19, 2024Peer-reviewedNeuroscience

Dynamic refinement of behavioural structure mediates dopamine-dependent credit assignment

Jonathan C. Y. Tang, Vítor Paixão, Filipe Carvalho, Artur Silva, Andreas Klaus, Joaquim Alves da Silva, Rui M. Costa

This study investigates how dopamine-dependent credit assignment refines behavioral structures through repeated reinforcement of specific actions and action sequences.

Nature · Dec 13, 2023Peer-reviewedNeuroscience