Luke Alexander Hammond

Two-timepoint assays of neural responses increase the sensitivity and specificity of single-cell whole-brain activity screens

This paper introduces a whole-brain screening method using two-timepoint assays to improve sensitivity and specificity in identifying neural responses, validated through studies on hunger, satiety, and semaglutide treatment.

The External Globus Pallidus is a Basal Ganglia Output Hub with Action-Specific Circuits

The paper reveals the external globus pallidus (GPe) as a basal ganglia output hub with distinct subpopulations that mediate specific behaviors through projection-specific circuits.

Clustered Inputs Maximize Efficiency for Stable Place Field Encoding in Hippocampal Pyramidal Neurons

The paper shows that clustered excitatory synapses on dendrites improve place field encoding efficiency in hippocampal neurons compared to randomized distributions.

A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson's Disease

The paper identifies a specific subtype of dopaminergic neurons, Anxa1+, that are selectively lost in Parkinson's disease and contribute to early motor symptoms.

RESPAN: A Deep Learning Pipeline for Accurate and Automated Restoration, Segmentation, and Quantification of Dendritic Spines

RESPAN improves dendritic spine quantification by integrating deep learning for restoration, segmentation, and analysis, achieving higher accuracy and usability than existing methods.

A brain atlas of the camouflaging dwarf cuttlefish, Sepia bandensis

The paper creates a brain atlas of the dwarf cuttlefish using MRI, deep learning, and histology, identifying 32 brain regions and providing an interactive web tool for data access.

Integrins protect nociceptive neurons in models of paclitaxel-mediated peripheral sensory neuropathy

This study identifies integrin overexpression as protective against paclitaxel-induced sensory neuron degeneration in Drosophila and mouse models of chemotherapy-induced peripheral neuropathy.

Tools for efficient analysis of neurons in a 3D reference atlas of whole mouse spinal cord

The paper develops tools for analyzing neurons in a 3D mouse spinal cord atlas, enabling high-throughput spatial mapping and comparison across studies.

An amygdala circuit mediates experience-dependent momentary exploratory arrests

The paper identifies an amygdala circuit that mediates experience-dependent momentary exploratory arrests in mice without affecting place preference or anxiety-like behaviors.