Jose Angel Obeso

This study investigates tier-specific vulnerability of dopaminergic neurons in non-human primates by analyzing Lewy body distribution and neuromelanin levels in different brain regions.

This paper describes the engineering of a PROTAC that uses p97-directed proteolysis to achieve specific substrate degradation without relying on E3 ubiquitin ligases.

The paper shows that surviving DA SN neurons after lesion recovery exhibit full in vivo firing range through Kv4.3-mediated pacemaker plasticity.

This study shows that dopamine neurons in the substantia nigra pars compacta encode contralateral movement vigor through transient activity, not general motivation.

The paper uses machine learning to identify neurodegeneration signatures in non-human primates caused by patient-derived α-synuclein structures, showing that small aggregates are as toxic as larger fibrils.

This paper reviews computational models of Parkinson’s disease to understand its mechanisms, neural dynamics, and treatments.