Yao Wang

NuMA promotes constitutive heterochromatin compaction by stabilizing linker histone H1 on chromatin

This study identifies NuMA's role in stabilizing linker histone H1 on chromatin to promote heterochromatin compaction and maintain epigenetic repression.

Viral evolution prediction identifies broadly neutralizing antibodies against existing and prospective SARS-CoV-2 variants

This paper predicts SARS-CoV-2 RBD evolution using deep mutational scanning to identify broadly neutralizing antibodies effective against existing and prospective variants.

Omicron-specific naive B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine

The paper investigates how Omicron-specific naive B cell maturation after breakthrough infection alleviates immune imprinting from inactivated SARS-CoV-2 vaccines.

Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain

This study identifies ultra-potent Omicron-specific antibodies targeting the N1/N2 loop of the Spike NTD, which neutralize SARS-CoV-2 by competing with ACE2 and blocking S1 shedding, but are evaded by BA.2.86 and BA.2.87.1 sublineages.

Transcription-coupled structural dynamics of topologically associating domains regulate replication origin efficiency

This study uses super-resolution imaging to show that replication origins are preferentially fired at the periphery of TADs due to chromatin re-organization linked to transcription and CTCF.