Cortical Overgrowth in a Preclinical Forebrain Organoid Model of CNTNAP2-Associated Autism Spectrum Disorder
Job O. de Jong, Ceyda Llapashtica, Matthieu Genestine, Kevin A. Strauss, Frank A. Provenzano, Yan Sun, Huixiang Zhu, Giuseppe P. Cortese, Francesco Gavino Brundu, Karlla Welch Brigatti, Barbara Corneo, Bianca Migliori, Raju Tomer, Steven A. Kushner, Christoph Kellendonk, , Sander Markx
This study uses patient-derived forebrain organoids to investigate the effects of a CNTNAP2 mutation on cortical development, finding increased cell proliferation and differential gene expression associated with ASD.
Nature Communications · Sep 1, 2021Peer-reviewedNeuroscience