Rosela Golloshi

Polymer Model Integrates Super-Resolution Imaging and Epigenomic Sequencing to Elucidate the Role of Epigenetic Reactions in Shaping 4D Chromatin Organization

The paper develops a polymer model integrating super-resolution imaging and epigenomic sequencing to show how epigenetic reactions shape 4D chromatin organization and influence gene expression and metastatic potential.

Deciphering Pre-existing and Induced 3D Genome Architecture Changes involved in Constricted Melanoma Migration

The paper identifies 3D genome architecture changes in melanoma cells before and after constricted migration, linking them to migration ability and cell fate changes.

Constricted migration is associated with stable 3D genome structure differences in cancer cells

This study shows that constricted migration in cancer cells leads to stable 3D genome structure changes associated with increased migration efficiency and altered gene expression.

Loops, TADs, Compartments, and Territories are Elastic and Robust to Dramatic Nuclear Volume Swelling

The paper investigates how genome structure responds to nuclear swelling, finding that global topology remains elastic and robust despite dramatic volume changes.

Radiation-Induced DNA Damage and Repair Effects on 3D Genome Organization

This study examines how DNA damage and repair affect 3D genome organization using Hi-C in different cell types, finding cell-type-specific changes and TAD boundary strengthening in repair-proficient cells.

Iteratively Improving Hi-C Experiments One Step at a Time

This paper evaluates Hi-C protocol modifications and identifies factors affecting data quality and DNA loss in Hi-C experiments.