Luiz Marcelo Oliveira

Fentanyl blockade of K+ channels contribute to Wooden Chest Syndrome

This study identifies fentanyl's off-target blockade of EAG-class potassium channels in motoneurons as a mechanism underlying Wooden Chest Syndrome, independent of opioid receptor activation.

An inspiration-off attractor supports the robust and flexible control of breathing

The paper identifies an inspiration-off attractor mechanism that enables robust and flexible breathing control through GABAergic and glutamatergic signaling interactions in the VRC.

Functional Modulation of Retrotrapezoid Neurons Drives Fentanyl-Induced Respiratory Depression

This study shows that activating RTN Phox2b+/Nmb+ neurons can counteract fentanyl-induced respiratory depression.

Ndufs4 inactivation in glutamatergic neurons reveals swallow-breathing discoordination in a mouse model of Leigh Syndrome

This study shows that Ndufs4 knockout in glutamatergic neurons of mice leads to swallow-breathing discoordination, contributing to weight loss and early death, which is rescued by chronic hypoxia.

AAV-mediated interneuron-specific gene replacement for Dravet syndrome

This study demonstrates that interneuron-specific AAV-mediated SCN1A gene replacement significantly rescues Dravet syndrome symptoms in mouse models.

Chronic Intermittent Hypoxia reveals role of the Postinspiratory Complex in the mediation of normal swallow production

This study investigates how chronic intermittent hypoxia affects swallow behavior by examining the role of the Postinspiratory Complex in swallow-breathing coordination and motor patterning.

Postinspiratory complex acts as a gating mechanism regulating swallow-breathing coordination and other laryngeal behaviors

This study identifies the postinspiratory complex (PiCo) as a central gating mechanism that coordinates swallow and breathing behaviors through optogenetic experiments in mice.