Thiago Santos Moreira

Fentanyl blockade of K+ channels contribute to Wooden Chest Syndrome

This study identifies fentanyl's off-target blockade of EAG-class potassium channels in motoneurons as a mechanism underlying Wooden Chest Syndrome, independent of opioid receptor activation.

Functional Modulation of Retrotrapezoid Neurons Drives Fentanyl-Induced Respiratory Depression

This study shows that activating RTN Phox2b+/Nmb+ neurons can counteract fentanyl-induced respiratory depression.

Phox2b mutation mediated by Atoh1 expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapnia

This study shows that conditional Phox2b mutation in Atoh1-derived cells impairs respiratory rhythm and ventilatory responses to hypoxia and hypercapnia in mice.

Vascular control of the CO2/H+ dependent drive to breathe

The paper identifies P2Y2 receptors in RTN vascular smooth muscle cells as essential for CO2/H+ chemoreception and respiratory behavior in mice.

Adrenergic C1 neurons are part of the circuitry that recruits active expiration in response to hypoxia

The paper identifies C1 neurons as part of the circuitry that drives active expiration during hypoxia by projecting to the pFRG and modulating its activity.