Aguan Daniel Wei

This study evaluates lentiviral vector delivery of SCN1A transgenes, finding that sequence optimization and epigenetic factors affect long-term expression.

This study identifies fentanyl's off-target blockade of EAG-class potassium channels in motoneurons as a mechanism underlying Wooden Chest Syndrome, independent of opioid receptor activation.

This study identifies PMPL-1 as a cofactor required for PEEL-1 toxin-induced cell death in C. elegans and shows that the toxin-antidote system creates a cation channel.

This study demonstrates that interneuron-specific AAV-mediated SCN1A gene replacement significantly rescues Dravet syndrome symptoms in mouse models.