Author

Tania M. Larrinaga

Icahn School of Medicine at Mount SinaiORCID 0000-0002-4091-1808Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Carol C. GregorioiD· 2 shared Alla S. KostyukovaiD· 1 shared Cristina M. RisiiD· 1 shared Sandeep ChoubeyiD· 1 shared Shashank ShekhariD· 1 shared Sudipta Biswas· 1 shared Vitold E. GalkiniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 12 mutual co-author links

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2 shared papersBiophysics

Carol C. GregorioORCID

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2 papers

Recent·Most cited

Structure of the Leiomodin-2 Regulated Actin Filament Pointed End Assembly from Profilactin

Cristina M. Risi, Tania M. Larrinaga, Alla S. Kostyukova, Carol C. Gregorio, Vitold E. Galkin

This study uses cryo-EM to reveal how Lmod2 stabilizes actin subunits at the pointed end of filaments and promotes elongation by introducing strain.

bioRxiv · May 18, 2026 · PreprintBiophysics

Leiomodin 2 functions as a processive pointed-end elongator of actin filaments

Sudipta Biswas, Tania M. Larrinaga, Sandeep Choubey, Carol C. Gregorio, Shashank Shekhar

This study identifies Leiomodin 2 as a processive actin polymerase that elongates pointed ends of actin filaments, linking its dysfunction to dilated cardiomyopathy.

bioRxiv · May 7, 2026 · PreprintBiochemistry