Shashank Shekhar

This study identifies Leiomodin 2 as a processive actin polymerase that elongates pointed ends of actin filaments, linking its dysfunction to dilated cardiomyopathy.

This study shows that Tpm isoforms in yeast bind actin filaments independently of formin isoforms and exhibit functional redundancy in actin cable maintenance.

The paper develops a generalized kinetic model to understand how multiple actin-binding proteins regulate filament length dynamics in vivo.

This study shows that TWF-2, a twinfilin ortholog in C. elegans, modulates actomyosin contractility in the spermatheca by regulating F-actin levels.

This study shows cofilin and CAP promote depolymerization of ADP-Pi actin filaments, though at lower rates than ADP filaments, suggesting new pathways for actin filament disassembly.

This study reveals that CAP is a processive depolymerase of actin filaments, removing subunits from both barbed and pointed ends, and interacts with formin and capping protein.