Author

Marcus G. Pezzolesi

University of UtahORCID 0000-0002-4093-3783Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:variant calling· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

DEVORAH STUCKI· 2 shared José M. Lázaro-GuevaraiD· 2 shared Melissa H. Pezzolesi· 2 shared William L. HollandiD· 2 shared A. Hunter Wright· 1 shared Adam M. Smiles· 1 shared Ademuyiwa S. AromolaraniD· 1 shared Adrian M VelardeiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCell Biology

DEVORAH STUCKI

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Excessive Ca2+-dependent ER-mitochondrial contact stabilization by EFHD1 drives liver injury

David Eberhardt, Emma C. Rekate, Yasmin B Masini, Hannah E. Duron, David M. Mollinedo, Adrian M Velarde, DEVORAH STUCKI, Tara R. Price, Sandra H. J. Lee, Enrique Balderas, Neeraj K Rai, Ashley R. Bratt, Anthony M. Balynas, Chris Stubben, Ryan D. Bia, , Dipayan Chaudhuri

This study identifies EFHD1 as a Ca2+-dependent stabilizer of ER-mitochondrial contacts that drives liver injury in MASH by promoting mitochondrial fragmentation and antiviral stress responses.

bioRxiv · Feb 16, 2026 · PreprintCell Biology

A Draft Pacific Ancestry Pangenome Reference

Connor Littlefield, José M. Lázaro-Guevara, DEVORAH STUCKI, Michael Lansford, Melissa H. Pezzolesi, Emma J. Taylor, Etoni-Ma’asi C. Wolfgramm, Jacob Taloa, Kime Lao, Carlos Dave C. Dumaguit, Perry G. Ridge, Justina P. Tavana, William L. Holland, Kalani L. Raphael, Marcus G. Pezzolesi

The paper develops a Pacific ancestry pangenome reference to improve genetic analysis for an underserved population, showing it reduces variant call errors and captures novel sequence.

bioRxiv · Aug 7, 2024 · PreprintGenomics

Targeted Next-Generation Sequencing Identifies Pathogenic Variants in Kidney Disease-Related Genes in Patients with Diabetic Kidney Disease

José M. Lázaro-Guevara, Julio C. Fierro Morales, A. Hunter Wright, River Gunville, Christopher Simeone, Scott G. Frodsham, Melissa H. Pezzolesi, Courtney A. Zaffino, Laith Farah Al-Rabadi, Nirupama Ramkumar, Marcus G. Pezzolesi

This study uses targeted next-generation sequencing to identify rare pathogenic variants in kidney disease-related genes in patients with diabetic kidney disease and non-diabetic kidney disease.

American Journal of Nephrology · Jan 1, 2021Peer-reviewedGenetics

Genome-wide association study of diabetic kidney disease highlights biology involved in renal basement membrane collagen

Rany M. Salem, Jennifer N. Todd, Niina Sandholm, Joanne B. Cole, Wei‐Min Chen, Darrel Andrews, Marcus G. Pezzolesi, Paul McKeigue, Linda T. Hiraki, Chengxiang Qiu, Viji Nair, Chen Di Liao, Jing Cao, Erkka Valo, Suna Önengüt-Gümüşcü, , José C. Florez

This study identifies 16 genome-wide significant loci associated with diabetic kidney disease, including a protective variant in the COL4A3 gene.

bioRxiv · Dec 19, 2018 · PreprintGenetics