William L. Holland

The paper shows that early β-adrenergic stimulation remodels adipose tissue in mice, leading to metabolic resilience against future obesity-induced insulin resistance.

This paper integrates clinical and transcriptomic data to identify LRRN4CL as a predictor of myocardial recovery in heart failure patients undergoing LVAD therapy, showing its association with cardiomyocyte dysfunction.

This study identifies EFHD1 as a Ca2+-dependent stabilizer of ER-mitochondrial contacts that drives liver injury in MASH by promoting mitochondrial fragmentation and antiviral stress responses.

This study investigates whether muscle-specific Keap1 deletion prevents inactivity-induced muscle atrophy in mice, finding it enhances force production but does not prevent atrophy or weakness after hindlimb unloading.

This study shows that mitochondrial cardiolipin deficiency disrupts electron transport chain function, leading to oxidative stress and promoting MASH in mice and humans.

The paper develops a Pacific ancestry pangenome reference to improve genetic analysis for an underserved population, showing it reduces variant call errors and captures novel sequence.

This study integrates clinical and transcriptomic data to predict myocardial recovery in heart failure patients after LVAD implantation, identifying 80 features with an AUC of 0.731.

The paper identifies genetic drivers of plasma lipoproteins in mice and links them to human lipid traits using QTL analysis and GWAS integration.

The paper identifies Abhd2 as an enzyme involved in metabolizing phosphatidylcholine and cardiolipin using genetic and lipidomic data from Diversity Outbred mice.