Excessive Ca2+-dependent ER-mitochondrial contact stabilization by EFHD1 drives liver injury
David Eberhardt, Emma C. Rekate, Yasmin B Masini…·Dipayan Chaudhuri
This study identifies EFHD1 as a Ca2+-dependent stabilizer of ER-mitochondrial contacts that drives liver injury in MASH by promoting mitochondrial fragmentation and antiviral stress responses.