Xin Gu

Ribosome remodeling drives translation adaptation during viral infection and cellular stress

The paper shows that ribosome remodeling enables enhanced viral protein synthesis during infection and cellular stress by altering ribosome composition and structure.

Structure of the TXNL1-bound proteasome

The paper reports the cryo-EM structure of TXNL1-bound proteasome and identifies interactions critical for stress-induced degradation of TXNL1.

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma

This study reveals the structural basis of the midnolin-proteasome pathway and shows that midnolin downregulation promotes myeloma cell survival by enhancing IRF4 expression.