Patrick Oeckl

The huntingtin-HAP40 complex is a bidirectional cellular rheostat

The paper shows the HTT-HAP40 complex acts as a bidirectional rheostat regulating stress response and lipid metabolism, with loss of balance linked to Huntington's disease pathogenesis.

RIG-I mediated neuron-specific IFN type 1 signaling in FUS-ALS induces neurodegeneration and offers new biomarker-driven individualized treatment options for (FUS-)ALS

The paper identifies RIG-I-mediated innate immune activation in FUS-ALS spinal motor neurons due to mitochondrial dsRNA accumulation, which can be targeted by JAK-STAT inhibition, offering potential biomarker-driven treatment options.

Loss of FXR1 and FXR2 promotes accumulation of TDP-43 in aging-related stress granules

The paper shows that loss of FXR1 and FXR2 leads to TDP-43 accumulation in stress granules, linking FXP family reduction to neurodegenerative pathology.

Molecular aging is the main driver of Parkinson's Disease

This study shows that aging processes drive Parkinson's Disease in a mouse model, independent of alpha-synuclein oligomers, by targeting CDC42 activity.

Most L1CAM is not associated with extracellular vesicles in human biofluids and iPSC-derived neurons

The paper validates EV isolation from multiple biofluids using orthogonal methods but finds L1CAM does not reliably enrich for neuron-derived EVs.