Gangliosides Modulate the Secretion of Extracellular Vesicles and Their Misfolded Protein Cargo
John Monyror, Vaibhavi Kadam, Luis Carlos Morales, Diego Ordóñez, Jeremies Ibanga, Asifa K. Zaidi, Emily McNamara, Desmond Pink, Magnus J. Stenlund, Ken Reyes, Aislinn D. Maguire, Jing Huang, Leonardo M. Cortez, Valerie L. Sim, Sue‐Ann Mok, , Simonetta Sipione
This study shows gangliosides modulate EV secretion and misfolded protein cargo, with GM1 enhancing EV release and reducing mutant huntingtin burden in HD models.
Science Advances · Sep 17, 2025Peer-reviewedCell Biology