Stefan Hauser

A synthetic xeno-free extracellular matrix surrogate supports robust human induced pluripotent stem cell maintenance and multilineage differentiation

This study demonstrates that BIOINSTRUCT, a synthetic extracellular matrix surrogate, supports robust human iPSC maintenance and multilineage differentiation comparable to Matrigel.

Deep axonal proteomics of human iPSC-derived neurons by microfluidic separation and DIA-MS

This paper reports the deepest human axonal proteome to date using microfluidic separation and DIA-MS on iPSC-derived neurons, identifying axon-enriched proteins and disease-related pathways.

Comprehensive investigation of AAV tropism across human iPSC-derived neuronal subtypes

This study evaluates AAV transduction efficiency and toxicity across human iPSC-derived neuronal subtypes, identifying optimal serotypes for gene delivery in vitro.

Long-Read RNA-sequencing reveals transcript-specific regulation in human-derived cortical neurons

This study uses long-read RNA sequencing to analyze transcript diversity and regulation in human fibroblasts, induced pluripotent stem cells, and cortical neurons, revealing transcript-specific changes in disease-related genes.

Most L1CAM is not associated with extracellular vesicles in human biofluids and iPSC-derived neurons

The paper validates EV isolation from multiple biofluids using orthogonal methods but finds L1CAM does not reliably enrich for neuron-derived EVs.

Human organoid model of PCH2a recapitulates brain region-specific pathology

This study develops human organoid models of PCH2a to investigate brain region-specific pathology, finding size reductions in cerebellar organoids and altered proliferation kinetics.

Unraveling Axonal Transcriptional Landscapes: Insights from iPSC-Derived Cortical Neurons and Implications for Motor Neuron Degeneration

This study uses microfluidic RNA-seq to analyze axonal transcriptomes from iPSC-derived neurons, revealing unique transcriptional features and highlighting the role of KIF1C in axonal health and neurodegeneration.