Author

Hsin-Hung Lin

Institute of Statistical Science, Academia SinicaORCID 0000-0002-4139-7089Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Organism:virus· 1 Organism:yeast· 1

Frequent Co-Authors

Wei‐Hau ChangiD· 3 shared I‐Ping TuiD· 2 shared Amy LarsoniD· 1 shared Cheng-Fu KaoiD· 1 shared Chia-Ling HsuiD· 1 shared Chung-Shu YehiD· 1 shared Fu-Lung YehiD· 1 shared Hsin‐Yue TsaiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

Wei‐Hau ChangORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 1, 2026

Structure-inspired design of Nsp8-based protein inhibitors to suppress SARS-CoV-2 replication

Petra Štěrbová, Hsin-Hung Lin, I‐Ping Tu, Wei‐Hau Chang

The paper designs truncated nsp8 proteins to inhibit SARS-CoV-2 replication by disrupting the nsp12-nsp7-nsp8 complex through competitive binding.

DOI 10.64898/2026.08.30.747997

virusexperimental assay

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BiophysicsProceedings of the National Academy of SciencesPeer-reviewedJun 29, 2026

Structural underpinning of multi-functionality of TFIIE-related tandem-winged-helix in RNA polymerase III

Jheng-Syong Wu, Yi‐Cheng Lin, Yi-Yu Wei…·Wei‐Hau Chang

The paper investigates the structural dynamics of the tWH domain in RNA polymerase III using smFRET and reveals multiple docking sites that explain its multi-functionality.

DOI 10.1073/pnas.2601775123

microscopy & imaging analysischromatin & epigenetic regulation

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BiochemistrybioRxivPreprintOct 29, 2025

A topologically conserved unstructured region helps positioning the evolutionarily conserved Prp40 WW domains to promote non-canonical intron splicing

Luh Tung, Chung-Shu Yeh, Hsin-Hung Lin…·Tien‐Hsien Chang

This paper identifies a conserved unstructured region in Prp40 WW domains that facilitates their positioning to promote non-canonical intron splicing in yeast.

DOI 10.1101/2025.10.29.685309

yeastexperimental assay

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