Author

Denis Grandgirard

University of BernORCID 0000-0002-4151-5196Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Stephen L. LeibiD· 3 shared Ngoc Dung LeiD· 2 shared Alexander ErnstiD· 1 shared Amal FahmiiD· 1 shared Andrew C. OatesiD· 1 shared Antoinette Golomingi· 1 shared Ayisha Marwa MPiD· 1 shared Daniel RůžekiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersMicrobiology

Stephen L. LeibORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Bemnifosbuvir and remdesivir inhibit tick-borne encephalitis virus infection in complementary in vitro and ex vivo disease models

Simone Leoni, Isabel Schultz-Pernice, Zuzana Krátka, Lucie Freiholz, Amal Fahmi, Teodora David, Antoinette Golomingi, Fabian Blank, Michaela Beránková, Milan Dejmek, Denis Grandgirard, Ronald Dijkman, Daniel Růžek, Luděk Eyer, Marco P. Alves, Stephen L. Leib

This study evaluates remdesivir and bemnifosbuvir's efficacy against TBEV in vitro and ex vivo, finding dose-dependent viral load reduction with notable cytotoxicity for remdesivir.

Antiviral Research · May 24, 2026Peer-reviewedMicrobiology

Identification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platform

Alexander Ernst, Indre Piragyte, Ayisha Marwa MP, Ngoc Dung Le, Denis Grandgirard, Stephen L. Leib, Andrew C. Oates, Nadia Mercader

The paper evaluates the effects of 162 FDA-approved drugs on zebrafish embryogenesis and immune response to SARS-CoV-2 spike protein, identifying potential developmental side effects.

Scientific Reports · Oct 9, 2023Peer-reviewedDevelopmental Biology

Repetitive Transcranial Magnetic Stimulation Activates Glial Cells and Inhibits Neurogenesis after Pneumococcal Meningitis

Lukas Muri, Simone Oberhänsli, Michelle C. Buri, Ngoc Dung Le, Denis Grandgirard, Rémy Bruggmann, René M. Müri, Stephen L. Leib

This study shows that cTBS increases neuroinflammation and inhibits neurogenesis after pneumococcal meningitis in rats.

PLoS ONE · Sep 11, 2020Peer-reviewedNeuroscience