Konstantin G. Arbeev

The paper examines the relationship between erythrocyte count and mortality in older adults, finding a critical threshold below which mortality risk sharply increases.

This study identifies age and survival-related transcriptomic signatures in longevity-enriched cohorts using RNAseq data from blood samples.

The paper uses causal mediation analysis on ADNI data to show that hippocampal volume mediates the link between NECTIN2 rs6859 polymorphism and Alzheimer's disease risk.

This study identifies genetic variants associated with cognitive domains like memory and attention using GWAS in the Long Life Family Study, finding domain-specific genetic architecture.

This study finds that high blood glucose levels are associated with brain hypometabolism progression, with HDL-C and APOE4 further contributing to this association.

The paper investigates how APOE4 and infections together contribute to brain glucose hypometabolism, a marker of Alzheimer's pathology, using ADNI data.

This study finds that the AD risk SNP rs6859 in NECTIN2 partly mediates its association with AD through increased pTau-181 levels in CSF.

A GWAS identified 20 rare genetic variants associated with better processing speed in the Long Life Family Study, replicated in Danish twin cohorts.

The paper introduces MXP, a framework for building bioinformatics pipelines, and demonstrates its flexibility and utility in GWAS and post-GWAS analysis.