Thomas T. Perls

hypeR-GEM: connecting metabolite signatures to enzyme-coding genes via genome-scale metabolic models

hypeR-GEM connects metabolite signatures to enzyme-coding genes using genome-scale metabolic models, showing concordance with proteomic and transcriptomic data in real-world applications.

Evidence of Epistatic Interactive Effects of HK1 and GCK Genes on Circulating Hemoglobin A1c Levels

The paper identifies epistatic interactions between HK1 and GCK genes affecting HbA1c levels using Bayesian methods and confirms findings in independent studies.

METABOLOMIC SIGNATURES OF EXTREME OLD AGE: FINDINGS FROM THE NEW ENGLAND CENTENARIAN STUDY

The paper identifies metabolomic signatures associated with extreme old age using data from the New England Centenarian Study and links them to biological age and mortality risk.

Whole blood transcriptional signatures of age and survival identified in Long Life Family and Integrative Longevity Omics Studies

This study identifies age and survival-related transcriptomic signatures in longevity-enriched cohorts using RNAseq data from blood samples.

Genetic Modifiers of Cognitive Function: Novel Genetic Associations with Memory, Executive Function, and Attention in the Long Life Family Study

This study identifies genetic variants associated with cognitive domains like memory and attention using GWAS in the Long Life Family Study, finding domain-specific genetic architecture.

IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures

The paper uses iPSC-derived neurons from centenarians to identify resilience signatures associated with longevity, showing enhanced stress response and specific transcriptional programs.

Utility of Polygenic Risk Scores in Families with Exceptional Longevity

This study evaluates polygenic risk scores (PRS) for predicting Alzheimer's disease risk in a cohort of families with exceptional longevity and finds limited predictive power due to population-specific genetic differences.

Increased Genetic Protection Against Alzheimer's Disease in Centenarians

This study constructs a polygenic protective score for Alzheimer's disease and finds stronger genetic protection against AD in centenarians compared to non-longevity individuals.

Robust Serum Proteomic Signatures of APOE2

The paper validates and expands a serum protein signature associated with APOE genotypes, identifying new protein associations and potential targets for Alzheimer's disease prevention.

Integrative analysis across metagenomic taxonomic classifiers: A case study of the gut microbiome in aging and longevity

This study compares two metagenomic classifiers, finds classifier-specific results, and recommends integrating multiple classifiers to better capture age-associated taxa.

A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring

The paper establishes a resource of iPSCs from centenarians and their offspring to study human longevity and resilience.

Cross-platform proteomics signatures of extreme old age

The paper validates and expands a serum protein signature of extreme old age using LC-MS/MS, identifying 80 conserved proteins across platforms associated with aging pathways.

A Novel Gene ARHGAP44 for Longitudinal Changes in Glycated Hemoglobin (HbA1c) in Subjects without Type 2 Diabetes: Evidence from the Long Life Family Study (LLFS) and the Framingham Offspring Study (FOS)

The paper identifies ARHGAP44 as a novel gene associated with longitudinal changes in HbA1c in non-diabetic individuals using linkage and sequence analysis from two studies.

Rare Genetic Variants Correlate with Better Processing Speed

A GWAS identified 20 rare genetic variants associated with better processing speed in the Long Life Family Study, replicated in Danish twin cohorts.

Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring

The paper evaluates 54 polygenic risk scores in long-lived individuals and their offspring, finding lower genetic risk for Alzheimer's, CAD, and lupus, but not for dementia in long-lived individuals.

Cancer Diagnosis, Polygenic Risk, and Longevity-Associated Variants.

This study examines how polygenic risk scores for cancer and longevity-associated variants relate to cancer risk and finds that longevity scores do not significantly improve cancer risk prediction beyond cancer-specific scores.