Abraham Aviv

Erythrocyte Count, Anemia, and the Human Natural Lifespan Limit:Evidence from the Long Life Family Study

The paper examines the relationship between erythrocyte count and mortality in older adults, finding a critical threshold below which mortality risk sharply increases.

The Magnitude of Telomere Shortening per Cell Division In Vivo: Implications for Lifelong Hematopoiesis in Humans

This paper estimates the rate of telomere shortening per cell division in humans and uses it to infer hematopoietic stem cell division rates over a lifespan.

Determinants of telomere length across human tissues

The paper examines telomere length variation across 6,391 tissue samples from 952 individuals, showing tissue-specific differences, positive correlations between tissues, and associations with age and ancestry.

De novo mutations across 1,465 diverse genomes reveal novel mutational insights and reductions in the Amish founder population.

The paper analyzes de novo mutations in 1,465 genomes to show similar mutation rates across ancestries but reduced rates in the Amish population, with environmental factors possibly influencing mutation rates.

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

This study identifies genetic variants associated with epigenetic age acceleration and shows TERT's role in regulating the DNA methylation clock.