Stacy L. Andersen

The paper examines the relationship between erythrocyte count and mortality in older adults, finding a critical threshold below which mortality risk sharply increases.

The paper identifies metabolomic signatures associated with extreme old age using data from the New England Centenarian Study and links them to biological age and mortality risk.

This study identifies age and survival-related transcriptomic signatures in longevity-enriched cohorts using RNAseq data from blood samples.

This study identifies genetic variants associated with cognitive domains like memory and attention using GWAS in the Long Life Family Study, finding domain-specific genetic architecture.

The paper uses iPSC-derived neurons from centenarians to identify resilience signatures associated with longevity, showing enhanced stress response and specific transcriptional programs.

This study evaluates polygenic risk scores (PRS) for predicting Alzheimer's disease risk in a cohort of families with exceptional longevity and finds limited predictive power due to population-specific genetic differences.

This study identifies novel protective genetic variants associated with TMT-B performance using a family-based GWLS approach in the Long Life Family Study.

This study constructs a polygenic protective score for Alzheimer's disease and finds stronger genetic protection against AD in centenarians compared to non-longevity individuals.

The paper validates and expands a serum protein signature associated with APOE genotypes, identifying new protein associations and potential targets for Alzheimer's disease prevention.

This study compares two metagenomic classifiers, finds classifier-specific results, and recommends integrating multiple classifiers to better capture age-associated taxa.

The paper establishes a resource of iPSCs from centenarians and their offspring to study human longevity and resilience.

The paper validates and expands a serum protein signature of extreme old age using LC-MS/MS, identifying 80 conserved proteins across platforms associated with aging pathways.

A GWAS identified 20 rare genetic variants associated with better processing speed in the Long Life Family Study, replicated in Danish twin cohorts.

The paper evaluates 54 polygenic risk scores in long-lived individuals and their offspring, finding lower genetic risk for Alzheimer's, CAD, and lupus, but not for dementia in long-lived individuals.