Author

Joseph M. Rutkowski

Texas A&M UniversityORCID 0000-0002-4197-0236Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Bethany L. GoodlettiD· 2 shared Brett M. MitchelliD· 2 shared Justin G McDermottiD· 2 shared Shobana NavaneethabalakrishnaniD· 2 shared Alex OdermattiD· 1 shared Alexandra Chassot· 1 shared Ali SassiiD· 1 shared Aurélien PommieriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPathology

Bethany L. GoodlettORCID

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3 papers

Recent·Most cited

The Effects of Hypertension on Signaling Dynamics in Rare Renal Cell Types

Justin G McDermott, Bethany L. Goodlett, Shobana Navaneethabalakrishnan, Joseph M. Rutkowski, Brett M. Mitchell

The paper investigates how hypertension affects signaling dynamics in specific renal cell types using single-cell RNA sequencing and NicheNet analysis.

bioRxiv · Jan 26, 2026 · PreprintPathology

Nephron-associated Support Cell Transcriptional Plasticity Expands in Hypertension

Justin G McDermott, Bethany L. Goodlett, Shobana Navaneethabalakrishnan, Joseph M. Rutkowski, Brett M. Mitchell

The paper investigates transcriptional changes in nephron-associated support cells in hypertension and identifies 299 differentially expressed genes.

bioRxiv · Jan 17, 2026 · PreprintPathology

Tissular glucocorticoid reactivating enzyme 11beta-HSD1 drives pathogenic myofibroblast differentiation in chronic kidney disease

Grégoire Arnoux, David Legouis, Matthieu Tihy, Raphaël Yvon, Nicolas Liaudet, Seraina O. Moser, Hélène Poinot, Ali Sassi, Olga M. Lempke, Marylise Fernandez, Isabelle Monnay, Alexandra Chassot, Carole Bourquin, Solange Moll, Emmanuel Somm, , Eric Féraille

This study identifies 11beta-HSD1 as a driver of myofibroblast differentiation in CKD, showing its inhibition reduces fibrosis and improves renal function.

bioRxiv · Jan 9, 2025 · PreprintPhysiology