Teodoro Bottiglieri

The paper shows that glutaminolysis and mitochondrial metabolism are conditionally crucial for B cell differentiation and cytokine signaling, revealing metabolic regulation of plasma cell generation and cytokine receptor signaling.

This study identifies B-vitamin deficiencies and genetic variants in one-carbon metabolism pathways associated with cognitive impairment in Alzheimer's and Parkinson's disease.

This study shows that high dietary folic acid increases hypoxia-induced mortality and reduces climbing behavior in Drosophila melanogaster, without affecting brain apoptosis.

The paper presents a multi-organ metabolomics atlas in AD mouse models, identifying dysregulated metabolites and microbiome associations linked to oxidative stress and cognitive impairment.

The paper shows FTY720 rescues synaptic plasticity and memory in Alzheimer's model mice by correcting sphingolipid, polyamine, and phospholipid metabolism.

This study evaluates the interlaboratory reproducibility of the MxP(R) Quant 500 metabolomics/lipidomics kit across human and rodent blood samples, showing high consistency and reliability.

This study creates a mouse model with the MTHFR 677C>T variant and shows it causes cerebrovascular deficits, supporting its use in preclinical research on vascular dementia.