Leah C. Graham

The 677C>T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice

This study creates a mouse model with the MTHFR 677C>T variant and shows it causes cerebrovascular deficits, supporting its use in preclinical research on vascular dementia.

Deficiency of complement component C1Q prevents cerebrovascular damage and white matter loss in a mouse model of chronic obesity

This study shows that deficiency of C1QA prevents cerebrovascular damage and white matter loss in obese mice, suggesting a role for the complement cascade in obesity-induced brain pathology.

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease

The paper uses genetic mouse models to identify transcriptomic signatures of late-onset Alzheimer’s disease by comparing mouse gene modules with human brain modules.

Transcriptional profiling reveals running promotes cerebrovascular remodeling in young but not aged mice

This study shows that running promotes cerebrovascular remodeling in young mice but not aged mice, suggesting exercise may be more effective for dementia prevention when started early.