Author

Nadia Boufaied

McGill University Health CentreORCID 0000-0002-4533-7155Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

David P. LabbéiD· 2 shared Henry W. LongiD· 2 shared Leigh EllisiD· 2 shared Matthew L. FreedmaniD· 2 shared Myles A BrowniD· 2 shared Xintao QiuiD· 2 shared Adrienne LuomaiD· 1 shared Anna de PoloiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCancer Biology

David P. LabbéORCID

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2 papers

Recent·Most cited

EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer

Beatriz German, Katherine L. Morel, Teia Noel, Nadia Boufaied, Deborah L. Burkhart, Sujun Chen, Felipe Segato Dezem, Xintao Qiu, Henry W. Long, Stefan DiFazio, Sylvan C. Baca, Ayesha A. Shafi, Matthew L. Freedman, Himisha Beltran, Christopher J. Sweeney, , Leigh Ellis

This paper identifies the EZH2-TTP-mTORC1 axis as a driver of phenotypic plasticity and therapeutic vulnerability in prostate cancer, showing that combined inhibition of EZH2 and PI3K/mTORC1 improves anti-tumor activity.

bioRxiv · Aug 7, 2025 · PreprintCancer Biology

MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets

Xintao Qiu, Nadia Boufaied, Tarek Hallal, Avery S. Feit, Anna de Polo, Adrienne Luoma, Walaa Alahmadi, Janie Larocque, Giorgia Zadra, Yingtian Xie, Shengqing Stan Gu, Qin Tang, Yi Zhang, Sudeepa Syamala, Ji-Heui Seo, , David P. Labbé

This study shows MYC overexpression disrupts AR transcriptional pause release, promoting aggressive prostate cancer progression.

Nature Communications · May 13, 2022Peer-reviewedGenomics