Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN knockout
Camille Goldman, Tatyana Kareva, Lily Sarrafha, Braxton Riley Schuldt, Abhishek Sahasrabudhe, Tim Ahfeldt, Joel W. Blanchard
The paper develops GEM-SCOPe, a modular fluorescent tool to study lysosomal and mitochondrial dysfunction in Parkinson's disease, identifying disease-related changes in organelle behavior.
iScience · Jun 3, 2025Peer-reviewedCell Biology