Yun Jiao

Cell type-resolved proteomics reveals intra- and intercellular signalingin Alzheimers disease

The paper presents a cell type-resolved proteomic atlas of Alzheimer's disease mouse models, identifying thousands of cell-specific protein changes and highlighting astrocyte-microglia signaling.

Single Plaque Proteomics Reveals the Composition and Dynamics of the Amyloid Microenvironment in Alzheimer's Disease

The paper quantifies the proteomic composition of amyloid plaques in AD models and human brains, revealing stage-dependent remodeling and conserved proteins across species.

Midkine Attenuates Aβ Fibril Assembly and Amyloid Plaque Formation

This study shows that midkine reduces Aβ fibril formation and amyloid plaque development in Alzheimer's disease models.

Spotiphy enables single-cell spatial whole transcriptomics across the entire section

Spotiphy transforms spatial transcriptomics data into single-cell-resolved whole-transcriptome images, revealing novel cellular compositions and spatial domains in Alzheimer's and breast tissue.

Human-mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome

Alzheimer's mouse model proteomes capture 30% (amyloid-only models) to 42% (adding tau and splicing models) of consensus human AD protein changes; in 5xFAD, plaques slow degradation of plaque-associated proteins.

Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with hyperphagocytosis and inflammatory neurodegeneration

This study shows that brain injury accelerates age-related microglial changes linked to hyperphagocytosis and neurodegeneration in old mice.

Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits

This study shows that removing microglia with a CSF1R inhibitor after TBI reduces neurodegeneration and improves neurological outcomes.