Serge Mostowy

Proximity biotinylation at the host-Shigella interface reveals UFMylation as an antibacterial pathway.

The paper identifies UFMylation as an antibacterial pathway using proximity biotinylation and mass spectrometry, showing it targets intracellular Shigella and Salmonella.

Genetic depletion in zebrafish uncovers requirement for septins in haematopoiesis

This study shows that septins are required for haematopoiesis in zebrafish, as septin-deficient larvae have increased HSPCs and myeloid bias, with implications for blood disorders.

Menaquinone depletion resensitises bedaquiline-resistant tuberculosis

This study identifies MenG inhibitors that restore bedaquiline susceptibility in resistant tuberculosis strains through menaquinone pathway disruption.

The Staphylococcus aureus LXG-domain toxins EsxX and SAR0287 do not promote virulence in a zebrafish larval infection model

Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei

This study identifies enhanced virulence and stress tolerance as factors contributing to the epidemiological success of Shigella sonnei, using zebrafish models and genomic analysis.

Telomerase reverse transcriptase is required for resistance to mycobacterial infection

This study shows that telomerase reverse transcriptase (Tert) is essential for resistance to mycobacterial infection by supporting demand-driven hematopoiesis in zebrafish.

A public resource of 15 genomically characterised representative strains of Shigella sonnei

The paper provides 15 genomically characterized Shigella sonnei isolates representing diverse sub-clades, with complete genome sequences and public availability for research.

Mimicry embedding for advanced neural network training of 3D biomedical micrographs

This paper introduces a mimicry embedding strategy to enable efficient deep learning for 3D biomedical micrographs by mimicking verified datasets.