Author

Max W. Shen

Broad InstituteORCID 0000-0002-4226-1861Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Max W. Shen1 paper

Biology Disciplines

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Bioinformatics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:machine learning (classical)· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Research Focus:software / tool· 1

Frequent Co-Authors

David R. LiuiD· 2 shared Alexander A. SousaiD· 1 shared Alvin HsuiD· 1 shared Amber N. McElroyiD· 1 shared Ana CristianiD· 1 shared Andrew V. AnzaloneiD· 1 shared Angus H. LiiD· 1 shared Benjamin J. SteinbeckiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

David R. LiuORCID

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Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivPreprintFeb 20, 2026

Mechanistic machine learning enables interpretable and generalizable prediction of prime editing outcomes

Alvin Hsu, Peter J. Chen, Angus H. Li…·David R. Liu

OptiPrime predicts prime editing outcomes with high accuracy, enabling efficient therapeutic applications in human and mouse cells.

DOI 10.64898/2026.02.20.706353

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BioinformaticsbioRxivPreprintJul 22, 2025

Deep Evolutionary Fitness Inference for Variant Nomination from Directed Evolution

Max W. Shen, Nathaniel Diamant, Christina Helmling…·Tommaso Biancalani

This paper introduces EVFI and DeepEVFI, machine learning methods that infer variant fitness from directed evolution data, identifying tighter binders missed by conventional approaches.

DOI 10.1101/2025.07.22.666175

machine learning (classical)variant effect prediction

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BioinformaticsNature CommunicationsPeer-reviewedFeb 15, 2021

PrimeDesign software for rapid and simplified design of prime editing guide RNAs

Jonathan Y. Hsu, Julian Grünewald, Regan N. Szalay…·Luca Pinello

PrimeDesign is a tool for designing prime editing guide RNAs, enabling single and combination edits, and it supports the creation of a database for over 68,500 pathogenic variants.

190 citationstop 1%

humanCRISPR screen

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