Robert G. Abrisch

Conformation governs cellular behaviors of LRRK2 Parkinson's disease variants

This study identifies 'unlatching' as a common mechanism for Parkinson's disease-associated LRRK2 variants, showing increased membrane localization and decreased S935 phosphorylation.

The molecular architecture of tunneling nanotubes

This study characterizes the molecular architecture of tunneling nanotubes (TNTs) using live-cell imaging and cryo-ET, revealing a complex structure with actin, microtubules, and organelles.

ER-associated control of axonal vesicle trafficking during neuronal development

The paper identifies ER-vesicle contact sites that regulate axonal vesicle trafficking during neuronal development, showing PRG1's role in modulating vesicle mobility and synapse formation.

β-Coronavirus Nsp6 hijacks host ER translocation machineries into viral replication centers

This study shows that Nsp6 of β-coronaviruses remodels ER membranes and sequesters host translocation machinery into DMVs to support viral replication.

Nuclear envelope budding is a non-canonical mechanism to export large transcripts in muscle cells

The paper demonstrates that nuclear envelope budding facilitates the export of large muscle-specific transcripts during myotube formation, involving UIF and ESCRT-III machinery.