Mingming Cao

This paper introduces a method to increase the proportion of correctly repaired hepatocytes in the liver through transient gene inhibition and transgene delivery, achieving a 25% increase in targeted cells and five-fold transgene expression.

The paper validates the effects of SNPs on gene expression in myeloid cells and finds that haplotype effects, not single variants, explain many associations.

The paper develops a Siamese convolutional neural network for CRISPR-Cas off-target scoring and shows that transfer learning improves performance on a curated benchmark dataset.