Giacomo Pasquini

This study shows that mTOR signalling, not clock gene rhythms, drives daily physiological variations in mammals and plants.

The paper introduces iClima, a ratiometric genetically encoded sensor for imaging GABAergic chloride currents, showing it can detect Cl- transients in vitro and in vivo with improved photostability and pH independence.

This study shows sleep deprivation impairs information processing in the prefrontal cortex by disrupting chloride homeostasis through KCC2 reduction and BDNF-TrkB signaling, which can be mitigated by bumetanide or AP synthesis blockade.