Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel
A. Gręda, Jemila P. Gomes, Vanessa Schmidt, Ewa Żurawska-Płaksej, Raphaela Fritsche‐Guenther, Ina‐Maria Rudolph, Narasimha Swamy Telugu, Cagla Cömert, Jennifer Kirwan, Séverine Kunz, Michael Rothe, Mogens Johannsen, Sebastian Diecke, Peter Bross, Thomas E. Willnow
The paper shows sortilin mediates neuronal uptake of fatty acids via apoE, enabling their use as metabolic fuel, but this pathway is disrupted by apoE4, linked to Alzheimer's risk.
Nature Metabolism · Oct 16, 2025Peer-reviewedNeuroscience