Narasimha Swamy Telugu

This paper shows that rs11218343 affects SORL1 expression in microglia, with increased expression linked to reduced inflammation, but the variant itself is not directly functional.

The paper shows sortilin mediates neuronal uptake of fatty acids via apoE, enabling their use as metabolic fuel, but this pathway is disrupted by apoE4, linked to Alzheimer's risk.

This study identifies a novel role for SORLA in regulating exosome release and neurotrophic function, linking SORL1 mutations to Alzheimer's disease pathology.

This study shows that mutant Huntingtin causes neurodevelopmental issues in human brain organoids by disrupting CHCHD2, leading to mitochondrial and metabolic problems.

This study shows that CEP83 deficiency in hiPSCs disrupts intermediate mesoderm differentiation, leading to impaired kidney progenitor formation and increased LPM marker expression.

The paper uses fluorescence spectroscopy to track β1/2-AR membrane abundance in differentiating hiPSC-derived cardiomyocytes and compares it to mRNA levels in WT and knock-in clones.