Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling
Antonino Asaro, Anne‐Sophie Carlo‐Spiewok, Anna R. Malik, Michael Rothe, Carola G. Schipke, Oliver Peters, Jöerg Heeren, Thomas E. Willnow
This study shows apoE4 disrupts sortilin's role in neuronal lipid metabolism and endocannabinoid signaling, contributing to Alzheimer's disease risk.
Alzheimer s & Dementia · Jun 25, 2020Peer-reviewedNeuroscience